Enables calcium ion binding activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; positive regulation of myeloid cell differentiation; and positive regulation of sodium:proton antiporter activity. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TESC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TESC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TESC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:116,818,976–116,819,922 | 280.0 kb | Distal (>10kb) Multiome | 760 | |
| chr12:116,876,126–116,876,628 | 223.0 kb | Distal (>10kb) Multiome | 82 | |
| chr12:116,880,733–116,881,665 | 218.3 kb | Distal (>10kb) Multiome | 509 | |
| chr12:116,910,746–116,911,448 | 188.4 kb | Distal (>10kb) Multiome | 902 | |
| chr12:117,051,045–117,051,880 | 47.9 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr12:117,052,572–117,053,115 | 46.6 kb | Distal (>10kb) Multiome HiCAR | 88 | |
| chr12:117,098,887–117,099,725 | 136 bp | At TSS Multiome | 608 | |
| chr12:117,118,728–117,119,232 | 19.4 kb | Distal (>10kb) Multiome | 141 | |
| chr12:117,155,214–117,156,022 | 56.0 kb | Distal (>10kb) Multiome | 507 | |
| chr12:117,189,825–117,190,955 | 91.0 kb | Distal (>10kb) Multiome | 751 | |
| chr12:117,360,382–117,361,599 | 261.7 kb | Distal (>10kb) Multiome | 202 |
Genomic view of the TESC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.