TENM2

teneurin transmembrane protein 2 | KIAA1127, TEN2, Ten-M2, ODZ2

Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in retrograde trans-synaptic signaling by trans-synaptic protein complex. Located in cell-cell junction and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 DE-4.9 Developmental clusters: GC6

Biological processes 44 terms

Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)PML body (GO:0016605)PML body (GO:0016605)axon guidance (GO:0007411)calcium ion binding (GO:0005509)cell adhesion molecule binding (GO:0050839)cell junction (GO:0030054)cell-cell adhesion (GO:0098609)cell-cell junction (GO:0005911)dendrite (GO:0030425)dendritic spine (GO:0043197)dendritic spine (GO:0043197)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)filopodium (GO:0030175)filopodium (GO:0030175)glutamatergic synapse (GO:0098978)growth cone (GO:0030426)growth cone (GO:0030426)membrane (GO:0016020)negative regulation of transcription by RNA polymerase II (GO:0000122)neuron projection (GO:0043005)neuron projection (GO:0043005)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of filopodium assembly (GO:0051491)postsynaptic membrane (GO:0045211)postsynaptic membrane (GO:0045211)presynaptic membrane (GO:0042734)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)retrograde trans-synaptic signaling by trans-synaptic protein complex (GO:0098942)retrograde trans-synaptic signaling by trans-synaptic protein complex (GO:0098942)signal transduction (GO:0007165)signaling receptor binding (GO:0005102)signaling receptor binding (GO:0005102)synapse (GO:0045202)synapse (GO:0045202)synaptic membrane adhesion (GO:0099560)

Expression (TPM)

TFs regulating TENM2 0 TFs

Transcription factors with Perturb-seq knockdown data for TENM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TENM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TENM2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TENM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:166,073,765–166,075,834	904.0 kb	Distal (>10kb) Multiome HiCAR	382
chr5:166,369,124–166,370,376	609.2 kb	Distal (>10kb) Multiome HiCAR	257
chr5:166,742,810–166,743,628	235.8 kb	Distal (>10kb) Multiome	126
chr5:166,978,266–166,979,670	122 bp	At TSS Multiome	316
chr5:167,466,804–167,467,406	488.1 kb	Distal (>10kb) Multiome	82
chr5:167,517,224–167,517,995	538.7 kb	Distal (>10kb) Multiome	94
chr5:167,564,338–167,564,728	8.9 kb	Proximal (<10kb)	15
chr5:167,570,564–167,570,897	2.8 kb	Proximal (<10kb)	27
chr5:167,573,307–167,574,148	594.8 kb	Distal (>10kb) Multiome	207
chr5:167,795,878–167,796,512	817.2 kb	Distal (>10kb) Multiome	96
chr5:167,850,277–167,851,495	872.0 kb	Distal (>10kb) Multiome	224
chr5:168,047,104–168,048,497	1068.9 kb	Distal (>10kb) Multiome HiCAR	384

Genome Browser

Genomic view of the TENM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.