The protein encoded by this gene belongs to the Tudor family of proteins. This protein contains conserved Tudor domains and LOTUS domains. It is a component of RNA granules, which function in RNA processing. Mutations in this gene have been associated with cataract formation in mouse and human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for TDRD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TDRD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TDRD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:96,854,007–96,854,748 | 557.6 kb | Distal (>10kb) Multiome HiCAR | 699 | |
| chr9:97,220,933–97,222,786 | 190.4 kb | Distal (>10kb) Multiome | 231 | |
| chr9:97,231,971–97,232,981 | 179.6 kb | Distal (>10kb) Multiome | 260 | |
| chr9:97,238,002–97,238,892 | 173.6 kb | Distal (>10kb) Multiome | 684 | |
| chr9:97,306,799–97,308,104 | 104.8 kb | Distal (>10kb) Multiome | 182 | |
| chr9:97,386,832–97,387,759 | 24.9 kb | Distal (>10kb) Multiome | 555 | |
| chr9:97,406,616–97,406,784 | 5.3 kb | Proximal (<10kb) | 132 | |
| chr9:97,411,603–97,412,682 | 74 bp | At TSS Multiome | 864 | |
| chr9:97,419,540–97,419,943 | 7.4 kb | Proximal (<10kb) | 66 | |
| chr9:97,436,823–97,437,760 | 25.3 kb | Distal (>10kb) Multiome | 98 | |
| chr9:97,501,163–97,503,374 | 89.4 kb | Distal (>10kb) Multiome | 581 | |
| chr9:97,598,751–97,599,712 | 186.9 kb | Distal (>10kb) Multiome | 274 | |
| chr9:97,632,371–97,634,267 | 221.4 kb | Distal (>10kb) Multiome HiCAR | 1027 | |
| chr9:97,696,750–97,697,733 | 285.2 kb | Distal (>10kb) Multiome | 836 |
Genomic view of the TDRD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.