This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for TBXAS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBXAS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBXAS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:139,482,716–139,484,133 | 294.4 kb | Distal (>10kb) Multiome | 464 | |
| chr7:139,499,861–139,500,450 | 278.0 kb | Distal (>10kb) Multiome | 482 | |
| chr7:139,523,378–139,524,503 | 254.3 kb | Distal (>10kb) Multiome | 136 | |
| chr7:139,660,103–139,661,027 | 117.5 kb | Distal (>10kb) Multiome | 329 | |
| chr7:139,777,264–139,778,898 | 60 bp | At TSS Multiome | 657 | |
| chr7:139,783,741–139,783,987 | 5.6 kb | Proximal (<10kb) | 60 | |
| chr7:139,829,228–139,829,956 | 51.4 kb | Distal (>10kb) Multiome | 262 | |
| chr7:139,838,738–139,839,616 | 60.9 kb | Distal (>10kb) Multiome | 42 | |
| chr7:139,851,513–139,852,522 | 73.8 kb | Distal (>10kb) Multiome | 188 | |
| chr7:139,852,825–139,853,587 | 75.1 kb | Distal (>10kb) Multiome | 278 | |
| chr7:139,971,936–139,972,384 | 194.1 kb | Distal (>10kb) Multiome | 102 | |
| chr7:140,062,257–140,063,368 | 284.7 kb | Distal (>10kb) Multiome | 805 |
Genomic view of the TBXAS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.