The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for TAOK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAOK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAOK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:118,103,306–118,104,597 | 269.0 kb | Distal (>10kb) Multiome | 730 | |
| chr12:118,119,571–118,120,301 | 253.1 kb | Distal (>10kb) Multiome HiCAR | 62 | |
| chr12:118,120,669–118,121,341 | 252.0 kb | Distal (>10kb) Multiome HiCAR | 428 | |
| chr12:118,135,872–118,136,757 | 236.8 kb | Distal (>10kb) Multiome HiCAR | 914 | |
| chr12:118,371,358–118,372,072 | 820 bp | At TSS | 296 | |
| chr12:118,372,364–118,373,361 | 123 bp | At TSS Multiome | 792 | |
| chr12:118,376,094–118,377,029 | 3.5 kb | Proximal (<10kb) Multiome | 844 | |
| chr12:118,520,842–118,521,879 | 148.5 kb | Distal (>10kb) Multiome | 16 |
Genomic view of the TAOK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.