The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Transcription factors with Perturb-seq knockdown data for TAGLN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAGLN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAGLN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:159,780,492–159,781,699 | 144.6 kb | Distal (>10kb) Multiome | 641 | |
| chr1:159,853,905–159,855,297 | 70.8 kb | Distal (>10kb) Multiome | 474 | |
| chr1:159,899,910–159,900,706 | 25.3 kb | Distal (>10kb) Multiome | 349 | |
| chr1:159,915,918–159,916,996 | 9.1 kb | Proximal (<10kb) Multiome | 465 | |
| chr1:159,922,909–159,926,224 | 24 bp | At TSS Multiome | 922 | |
| chr1:159,929,315–159,930,329 | 4.2 kb | Proximal (<10kb) Multiome | 235 | |
| chr1:159,936,265–159,937,075 | 11.1 kb | Distal (>10kb) Multiome | 355 | |
| chr1:159,945,025–159,946,368 | 20.2 kb | Distal (>10kb) Multiome | 624 | |
| chr1:160,031,268–160,032,381 | 106.4 kb | Distal (>10kb) Multiome | 780 | |
| chr1:160,046,290–160,047,082 | 121.2 kb | Distal (>10kb) Multiome | 540 | |
| chr1:160,069,829–160,071,049 | 144.9 kb | Distal (>10kb) Multiome | 419 | |
| chr1:160,083,809–160,084,575 | 158.7 kb | Distal (>10kb) Multiome | 327 | |
| chr1:160,095,707–160,096,231 | 170.5 kb | Distal (>10kb) Multiome | 79 | |
| chr1:160,097,214–160,099,572 | 173.4 kb | Distal (>10kb) Multiome | 659 | |
| chr1:160,100,845–160,101,543 | 175.7 kb | Distal (>10kb) Multiome | 530 | |
| chr1:160,169,049–160,170,141 | 244.2 kb | Distal (>10kb) Multiome | 330 | |
| chr1:160,192,913–160,193,769 | 267.8 kb | Distal (>10kb) Multiome | 551 | |
| chr1:160,204,860–160,206,035 | 279.9 kb | Distal (>10kb) Multiome | 637 |
Genomic view of the TAGLN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.