This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Transcription factors with Perturb-seq knockdown data for TACC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TACC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TACC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:38,467,549–38,469,321 | 288.6 kb | Distal (>10kb) Multiome | 775 | |
| chr8:38,471,859–38,472,443 | 285.1 kb | Distal (>10kb) Multiome | 84 | |
| chr8:38,512,281–38,512,945 | 244.7 kb | Distal (>10kb) Multiome | 187 | |
| chr8:38,513,847–38,514,352 | 243.2 kb | Distal (>10kb) Multiome | 185 | |
| chr8:38,530,520–38,531,118 | 226.3 kb | Distal (>10kb) Multiome | 174 | |
| chr8:38,541,080–38,541,513 | 216.0 kb | Distal (>10kb) Multiome | 114 | |
| chr8:38,553,735–38,554,545 | 203.2 kb | Distal (>10kb) Multiome | 413 | |
| chr8:38,566,934–38,567,642 | 190.0 kb | Distal (>10kb) Multiome | 337 | |
| chr8:38,704,269–38,704,886 | 52.8 kb | Distal (>10kb) Multiome | 37 | |
| chr8:38,734,447–38,735,152 | 22.5 kb | Distal (>10kb) Multiome | 738 | |
| chr8:38,756,730–38,757,722 | 275 bp | At TSS Multiome | 535 | |
| chr8:38,770,080–38,770,606 | 13.0 kb | Distal (>10kb) Multiome | 340 | |
| chr8:38,786,808–38,788,320 | 29.9 kb | Distal (>10kb) Multiome | 620 | |
| chr8:38,899,958–38,902,158 | 144.2 kb | Distal (>10kb) Multiome | 565 | |
| chr8:38,973,978–38,975,173 | 217.3 kb | Distal (>10kb) Multiome | 205 | |
| chr8:38,995,870–38,997,751 | 239.4 kb | Distal (>10kb) Multiome | 913 | |
| chr8:39,029,145–39,029,788 | 272.1 kb | Distal (>10kb) Multiome | 74 |
Genomic view of the TACC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.