Enables alpha-actinin binding activity and filamin binding activity. Involved in positive regulation of actin filament bundle assembly; positive regulation of cell migration; and regulation of Rho-dependent protein serine/threonine kinase activity. Located in several cellular components, including Z disc; focal adhesion; and stress fiber. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SYNPO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYNPO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYNPO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:118,591,329–118,592,247 | 297.3 kb | Distal (>10kb) Multiome | 545 | |
| chr4:118,684,929–118,685,940 | 203.6 kb | Distal (>10kb) Multiome | 728 | |
| chr4:118,834,995–118,836,932 | 52.9 kb | Distal (>10kb) Multiome HiCAR | 861 | |
| chr4:118,848,578–118,848,736 | 1.9 kb | Proximal (<10kb) | 3 | |
| chr4:118,848,987–118,849,193 | 1.5 kb | Proximal (<10kb) | 12 | |
| chr4:118,849,832–118,849,968 | 718 bp | At TSS | 21 | |
| chr4:118,850,099–118,850,712 | 38.7 kb | Distal (>10kb) Multiome | 189 | |
| chr4:118,881,228–118,881,819 | 7.2 kb | Proximal (<10kb) | 44 | |
| chr4:118,888,513–118,889,224 | 119 bp | At TSS Multiome | 392 |
Genomic view of the SYNPO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.