This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SYNGR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYNGR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYNGR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:39,077,158–39,077,634 | 272.7 kb | Distal (>10kb) Multiome | 66 | |
| chr22:39,087,857–39,088,400 | 261.9 kb | Distal (>10kb) Multiome | 32 | |
| chr22:39,144,772–39,146,359 | 204.3 kb | Distal (>10kb) Multiome | 668 | |
| chr22:39,152,016–39,153,700 | 197.3 kb | Distal (>10kb) Multiome | 607 | |
| chr22:39,170,852–39,171,359 | 178.9 kb | Distal (>10kb) Multiome | 425 | |
| chr22:39,174,292–39,175,258 | 175.1 kb | Distal (>10kb) Multiome | 688 | |
| chr22:39,179,438–39,180,229 | 170.3 kb | Distal (>10kb) Multiome | 84 | |
| chr22:39,229,884–39,230,835 | 119.8 kb | Distal (>10kb) Multiome | 417 | |
| chr22:39,242,211–39,244,345 | 107.1 kb | Distal (>10kb) Multiome | 605 | |
| chr22:39,310,537–39,311,897 | 38.9 kb | Distal (>10kb) Multiome | 655 | |
| chr22:39,319,163–39,320,470 | 30.3 kb | Distal (>10kb) Multiome | 968 | |
| chr22:39,349,608–39,350,646 | 105 bp | At TSS Multiome | 412 | |
| chr22:39,388,249–39,388,891 | 38.5 kb | Distal (>10kb) Multiome | 336 | |
| chr22:39,399,211–39,400,196 | 49.8 kb | Distal (>10kb) Multiome | 896 | |
| chr22:39,501,766–39,502,757 | 152.3 kb | Distal (>10kb) Multiome | 736 | |
| chr22:39,519,211–39,521,337 | 170.2 kb | Distal (>10kb) Multiome | 1150 | |
| chr22:39,528,868–39,529,848 | 179.4 kb | Distal (>10kb) Multiome | 829 | |
| chr22:39,532,183–39,533,171 | 182.9 kb | Distal (>10kb) Multiome | 799 | |
| chr22:39,534,113–39,535,455 | 185.0 kb | Distal (>10kb) Multiome | 621 | |
| chr22:39,598,010–39,598,521 | 248.4 kb | Distal (>10kb) Multiome | 163 |
Genomic view of the SYNGR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.