SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
Transcription factors with Perturb-seq knockdown data for SUPT7L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUPT7L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUPT7L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:27,369,685–27,371,261 | 293.2 kb | Distal (>10kb) Multiome | 1096 | |
| chr2:27,380,026–27,381,202 | 282.9 kb | Distal (>10kb) Multiome | 821 | |
| chr2:27,408,972–27,410,056 | 254.0 kb | Distal (>10kb) Multiome | 989 | |
| chr2:27,428,202–27,429,633 | 235.0 kb | Distal (>10kb) Multiome | 1013 | |
| chr2:27,441,811–27,442,884 | 221.2 kb | Distal (>10kb) Multiome | 380 | |
| chr2:27,489,334–27,490,205 | 173.8 kb | Distal (>10kb) Multiome | 731 | |
| chr2:27,494,797–27,495,577 | 168.4 kb | Distal (>10kb) Multiome | 380 | |
| chr2:27,517,085–27,517,958 | 146.1 kb | Distal (>10kb) Multiome | 130 | |
| chr2:27,582,572–27,583,317 | 80.7 kb | Distal (>10kb) Multiome | 843 | |
| chr2:27,628,534–27,629,380 | 34.6 kb | Distal (>10kb) Multiome | 828 | |
| chr2:27,654,817–27,655,565 | 8.1 kb | Proximal (<10kb) | 53 | |
| chr2:27,663,338–27,664,216 | 98 bp | At TSS Multiome | 1035 | |
| chr2:27,681,105–27,682,049 | 18.0 kb | Distal (>10kb) Multiome | 85 | |
| chr2:27,715,293–27,715,981 | 52.3 kb | Distal (>10kb) Multiome | 346 | |
| chr2:27,735,279–27,736,049 | 72.0 kb | Distal (>10kb) Multiome | 395 | |
| chr2:27,752,465–27,753,359 | 89.2 kb | Distal (>10kb) Multiome | 577 | |
| chr2:27,771,346–27,772,271 | 108.1 kb | Distal (>10kb) Multiome | 941 | |
| chr2:27,889,901–27,891,358 | 227.0 kb | Distal (>10kb) Multiome | 1000 |
Genomic view of the SUPT7L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.