This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for STX16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STX16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STX16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:58,388,753–58,389,913 | 262.1 kb | Distal (>10kb) Multiome | 887 | |
| chr20:58,482,394–58,483,281 | 168.6 kb | Distal (>10kb) Multiome | 155 | |
| chr20:58,514,461–58,515,572 | 136.1 kb | Distal (>10kb) Multiome | 173 | |
| chr20:58,523,004–58,524,066 | 127.8 kb | Distal (>10kb) Multiome | 197 | |
| chr20:58,546,673–58,547,327 | 104.2 kb | Distal (>10kb) Multiome | 69 | |
| chr20:58,649,950–58,652,788 | 141 bp | At TSS Multiome | 1208 | |
| chr20:58,656,803–58,657,048 | 5.5 kb | Proximal (<10kb) | 20 | |
| chr20:58,669,288–58,669,967 | 18.4 kb | Distal (>10kb) Multiome | 158 | |
| chr20:58,692,413–58,693,477 | 41.5 kb | Distal (>10kb) Multiome | 317 | |
| chr20:58,850,471–58,851,960 | 199.7 kb | Distal (>10kb) Multiome | 308 | |
| chr20:58,852,406–58,852,990 | 201.5 kb | Distal (>10kb) Multiome | 172 | |
| chr20:58,888,196–58,892,842 | 237.8 kb | Distal (>10kb) Multiome | 977 |
Genomic view of the STX16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.