STT3A

STT3 oligosaccharyltransferase complex catalytic subunit A | MGC9042, STT3-A, TMC, ITM1

The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Member of: DE-7 Developmental clusters: GC1

Biological processes 25 terms

dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579)dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579)dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579)dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579)dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)glycoprotein biosynthetic process (GO:0009101)membrane (GO:0016020)membrane (GO:0016020)oligosaccharyl transferase activity (GO:0004576)oligosaccharyltransferase complex (GO:0008250)oligosaccharyltransferase complex (GO:0008250)oligosaccharyltransferase complex (GO:0008250)oligosaccharyltransferase complex A (GO:0160226)post-translational protein modification (GO:0043687)protein N-linked glycosylation (GO:0006487)protein N-linked glycosylation (GO:0006487)protein N-linked glycosylation (GO:0006487)protein N-linked glycosylation (GO:0006487)protein N-linked glycosylation (GO:0006487)protein binding (GO:0005515)protein co-translational transfer of dolichol-linked oligosaccharide (GO:0180058)

Expression (TPM)

TFs regulating STT3A 0 TFs

Transcription factors with Perturb-seq knockdown data for STT3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STT3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to STT3A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STT3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:125,330,306–125,331,087	262.1 kb	Distal (>10kb) Multiome	104
chr11:125,369,857–125,372,110	222.6 kb	Distal (>10kb) Multiome	226
chr11:125,404,667–125,405,169	187.9 kb	Distal (>10kb) Multiome	273
chr11:125,433,337–125,433,944	159.2 kb	Distal (>10kb) Multiome	170
chr11:125,443,557–125,444,361	148.8 kb	Distal (>10kb) Multiome	142
chr11:125,495,125–125,496,641	96.6 kb	Distal (>10kb) Multiome	422
chr11:125,505,583–125,506,532	86.9 kb	Distal (>10kb) Multiome	40
chr11:125,509,289–125,509,972	83.3 kb	Distal (>10kb) Multiome	165
chr11:125,568,984–125,569,972	23.4 kb	Distal (>10kb) Multiome	796
chr11:125,591,812–125,593,372	142 bp	At TSS Multiome	902
chr11:125,625,323–125,626,856	33.2 kb	Distal (>10kb) Multiome	1108
chr11:125,886,970–125,888,478	295.0 kb	Distal (>10kb) Multiome HiCAR	823

Genome Browser

Genomic view of the STT3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.