This gene encodes a Storkhead-box_winged-helix domain containing protein. This protein is differentially expressed in decidual tissue and may be involved in the susceptibility to pre-eclampsia with fetal growth restriction. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for STOX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STOX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STOX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:183,503,782–183,506,533 | 291.5 kb | Distal (>10kb) Multiome | 969 | |
| chr4:183,658,630–183,659,843 | 138.5 kb | Distal (>10kb) Multiome | 779 | |
| chr4:183,722,750–183,723,572 | 74.6 kb | Distal (>10kb) Multiome | 395 | |
| chr4:183,797,040–183,798,833 | 10 bp | At TSS Multiome | 400 | |
| chr4:183,799,877–183,800,069 | 2.2 kb | Proximal (<10kb) | 26 | |
| chr4:183,905,112–183,907,500 | 107.7 kb | Distal (>10kb) Multiome | 538 | |
| chr4:183,920,182–183,920,914 | 123.0 kb | Distal (>10kb) Multiome | 79 | |
| chr4:184,167,643–184,168,130 | 370.0 kb | Distal (>10kb) Multiome | 103 | |
| chr4:184,168,461–184,168,916 | 370.9 kb | Distal (>10kb) Multiome HiCAR | 352 |
Genomic view of the STOX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.