Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in regulation of MAPK cascade. Predicted to act upstream of or within several processes, including glycogen metabolic process; lung development; and respiratory system process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STK40. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK40 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK40, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:36,088,326–36,089,393 | 297.1 kb | Distal (>10kb) Multiome | 1023 | |
| chr1:36,148,864–36,150,075 | 236.4 kb | Distal (>10kb) Multiome | 925 | |
| chr1:36,150,344–36,151,320 | 234.9 kb | Distal (>10kb) Multiome | 524 | |
| chr1:36,155,033–36,157,490 | 229.9 kb | Distal (>10kb) Multiome | 790 | |
| chr1:36,166,478–36,167,190 | 219.1 kb | Distal (>10kb) Multiome | 85 | |
| chr1:36,176,148–36,176,823 | 209.5 kb | Distal (>10kb) Multiome | 141 | |
| chr1:36,178,119–36,179,461 | 206.9 kb | Distal (>10kb) Multiome | 222 | |
| chr1:36,187,827–36,188,464 | 197.7 kb | Distal (>10kb) Multiome | 572 | |
| chr1:36,223,459–36,225,047 | 161.6 kb | Distal (>10kb) Multiome | 1017 | |
| chr1:36,305,654–36,307,599 | 78.9 kb | Distal (>10kb) Multiome | 826 | |
| chr1:36,320,781–36,321,934 | 64.6 kb | Distal (>10kb) Multiome | 522 | |
| chr1:36,322,032–36,324,527 | 62.2 kb | Distal (>10kb) Multiome | 699 | |
| chr1:36,384,603–36,387,142 | 121 bp | At TSS Multiome | 1050 | |
| chr1:36,387,290–36,388,127 | 1.8 kb | Proximal (<10kb) Multiome | 280 | |
| chr1:36,397,267–36,398,140 | 12.0 kb | Distal (>10kb) Multiome | 787 | |
| chr1:36,400,687–36,401,905 | 15.4 kb | Distal (>10kb) Multiome | 721 | |
| chr1:36,449,991–36,450,940 | 64.6 kb | Distal (>10kb) Multiome | 725 | |
| chr1:36,463,701–36,464,970 | 78.5 kb | Distal (>10kb) Multiome | 1027 | |
| chr1:36,481,699–36,482,274 | 96.1 kb | Distal (>10kb) Multiome | 133 |
Genomic view of the STK40 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.