Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and negative regulation of autophagy. Acts upstream of or within protein phosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STK38L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK38L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK38L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:27,013,686–27,014,988 | 229.9 kb | Distal (>10kb) Multiome | 864 | |
| chr12:27,021,899–27,022,924 | 221.8 kb | Distal (>10kb) Multiome | 783 | |
| chr12:27,243,875–27,245,004 | 13 bp | At TSS Multiome | 897 | |
| chr12:27,249,563–27,250,058 | 5.3 kb | Proximal (<10kb) | 15 | |
| chr12:27,332,152–27,333,788 | 88.7 kb | Distal (>10kb) Multiome | 640 | |
| chr12:27,347,364–27,348,398 | 103.7 kb | Distal (>10kb) Multiome | 160 | |
| chr12:27,523,289–27,524,726 | 279.9 kb | Distal (>10kb) Multiome | 792 |
Genomic view of the STK38L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.