This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for ST6GAL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST6GAL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST6GAL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:106,737,320–106,737,880 | 149.5 kb | Distal (>10kb) Multiome | 140 | |
| chr2:106,761,626–106,762,564 | 125.0 kb | Distal (>10kb) Multiome | 22 | |
| chr2:106,869,115–106,870,209 | 17.4 kb | Distal (>10kb) Multiome | 206 | |
| chr2:106,882,804–106,883,095 | 3.1 kb | Proximal (<10kb) | 21 | |
| chr2:106,885,427–106,887,833 | 68 bp | At TSS Multiome | 407 | |
| chr2:106,960,445–106,962,134 | 74.3 kb | Distal (>10kb) Multiome | 249 | |
| chr2:107,078,201–107,079,328 | 191.6 kb | Distal (>10kb) Multiome | 83 | |
| chr2:107,093,489–107,094,603 | 206.7 kb | Distal (>10kb) Multiome | 161 |
Genomic view of the ST6GAL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.