The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ST14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:129,894,845–129,896,318 | 264.2 kb | Distal (>10kb) Multiome | 678 | |
| chr11:130,001,573–130,003,849 | 157.0 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:130,068,597–130,071,216 | 90.1 kb | Distal (>10kb) Multiome | 898 | |
| chr11:130,076,579–130,077,560 | 82.8 kb | Distal (>10kb) Multiome | 129 | |
| chr11:130,146,013–130,146,727 | 13.3 kb | Distal (>10kb) Multiome | 413 | |
| chr11:130,159,259–130,160,341 | 78 bp | At TSS Multiome | 309 | |
| chr11:130,212,937–130,213,600 | 53.5 kb | Distal (>10kb) Multiome | 321 | |
| chr11:130,314,035–130,315,987 | 155.0 kb | Distal (>10kb) Multiome | 766 | |
| chr11:130,378,066–130,378,569 | 218.6 kb | Distal (>10kb) Multiome | 64 | |
| chr11:130,383,295–130,383,854 | 223.8 kb | Distal (>10kb) Multiome | 272 | |
| chr11:130,423,717–130,424,508 | 264.2 kb | Distal (>10kb) Multiome | 77 | |
| chr11:130,427,546–130,428,649 | 268.5 kb | Distal (>10kb) Multiome | 234 | |
| chr11:130,448,217–130,449,643 | 288.8 kb | Distal (>10kb) Multiome | 449 | |
| chr11:130,449,732–130,450,570 | 290.4 kb | Distal (>10kb) Multiome | 212 |
Genomic view of the ST14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.