This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for SNX15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:64,729,775–64,730,315 | 297.4 kb | Distal (>10kb) Multiome | 115 | |
| chr11:64,742,520–64,743,124 | 284.5 kb | Distal (>10kb) Multiome | 501 | |
| chr11:64,759,882–64,760,354 | 267.4 kb | Distal (>10kb) Multiome | 172 | |
| chr11:64,777,493–64,779,271 | 249.8 kb | Distal (>10kb) Multiome | 859 | |
| chr11:64,802,650–64,803,485 | 224.1 kb | Distal (>10kb) Multiome | 522 | |
| chr11:64,809,807–64,811,090 | 216.8 kb | Distal (>10kb) Multiome | 702 | |
| chr11:64,844,075–64,845,264 | 182.7 kb | Distal (>10kb) Multiome HiCAR | 645 | |
| chr11:64,846,953–64,847,598 | 180.2 kb | Distal (>10kb) Multiome HiCAR | 509 | |
| chr11:64,877,434–64,879,352 | 148.7 kb | Distal (>10kb) Multiome | 980 | |
| chr11:64,887,785–64,888,374 | 139.4 kb | Distal (>10kb) Multiome | 633 | |
| chr11:64,916,057–64,917,940 | 110.0 kb | Distal (>10kb) Multiome | 873 | |
| chr11:64,924,041–64,924,916 | 103.0 kb | Distal (>10kb) Multiome | 808 | |
| chr11:64,971,835–64,972,454 | 55.3 kb | Distal (>10kb) Multiome | 265 | |
| chr11:65,013,538–65,014,838 | 13.4 kb | Distal (>10kb) Multiome | 980 | |
| chr11:65,027,243–65,027,944 | 139 bp | At TSS Multiome | 851 | |
| chr11:65,040,595–65,041,884 | 13.7 kb | Distal (>10kb) Multiome | 838 | |
| chr11:65,083,636–65,084,788 | 56.8 kb | Distal (>10kb) Multiome | 898 | |
| chr11:65,095,834–65,097,052 | 69.0 kb | Distal (>10kb) Multiome | 1061 | |
| chr11:65,111,466–65,113,404 | 84.4 kb | Distal (>10kb) Multiome | 919 | |
| chr11:65,116,528–65,118,298 | 90.4 kb | Distal (>10kb) Multiome | 973 | |
| chr11:65,121,474–65,122,848 | 94.8 kb | Distal (>10kb) Multiome | 817 | |
| chr11:65,134,120–65,135,530 | 107.6 kb | Distal (>10kb) Multiome | 997 | |
| chr11:65,180,773–65,182,676 | 154.2 kb | Distal (>10kb) Multiome | 832 | |
| chr11:65,184,109–65,184,542 | 156.9 kb | Distal (>10kb) Multiome | 85 | |
| chr11:65,213,383–65,213,853 | 186.2 kb | Distal (>10kb) Multiome | 174 | |
| chr11:65,225,439–65,226,037 | 198.2 kb | Distal (>10kb) Multiome | 522 | |
| chr11:65,261,186–65,262,526 | 234.4 kb | Distal (>10kb) Multiome | 777 | |
| chr11:65,314,302–65,316,053 | 288.3 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the SNX15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.