Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMIM8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMIM8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMIM8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:87,151,562–87,152,822 | 170.4 kb | Distal (>10kb) Multiome | 359 | |
| chr6:87,154,802–87,156,695 | 167.2 kb | Distal (>10kb) Multiome | 1153 | |
| chr6:87,320,722–87,321,018 | 1.6 kb | Proximal (<10kb) | 41 | |
| chr6:87,322,367–87,323,025 | 31 bp | At TSS Multiome | 892 | |
| chr6:87,328,682–87,329,364 | 6.1 kb | Proximal (<10kb) | 81 | |
| chr6:87,407,486–87,408,928 | 85.6 kb | Distal (>10kb) Multiome | 735 | |
| chr6:87,472,409–87,473,809 | 150.5 kb | Distal (>10kb) Multiome | 913 | |
| chr6:87,483,840–87,484,329 | 161.6 kb | Distal (>10kb) Multiome | 125 | |
| chr6:87,551,523–87,552,511 | 229.2 kb | Distal (>10kb) Multiome | 64 | |
| chr6:87,589,655–87,590,489 | 267.5 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the SMIM8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.