SLC7A6
solute carrier family 7 member 6 | KIAA0245, LAT-2, LAT3, y+LAT-2

Enables L-lysine:L-arginine antiporter activity and arginine binding activity. Involved in L-arginine transmembrane transport; L-leucine transport; and ornithine transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 DE-4.19
Biological processes 28 terms
L-arginine transmembrane transport (GO:1903826)L-arginine transmembrane transport (GO:1903826)L-arginine transmembrane transport (GO:1903826)L-arginine transmembrane transporter activity (GO:0061459)L-arginine transmembrane transporter activity (GO:0061459)L-leucine transport (GO:0015820)L-leucine transport (GO:0015820)L-lysine transmembrane transport (GO:1903401)L-lysine:L-arginine antiporter activity (GO:0106439)amino acid import across plasma membrane (GO:0089718)amino acid transmembrane transport (GO:0003333)amino acid transmembrane transport (GO:0003333)amino acid transmembrane transporter activity (GO:0015171)arginine binding (GO:0034618)basic amino acid transmembrane transporter activity (GO:0015174)glycine betaine transport (GO:0031460)glycine betaine transport (GO:0031460)membrane (GO:0016020)neutral amino acid transport (GO:0015804)nitric oxide biosynthetic process (GO:0006809)ornithine transport (GO:0015822)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)transmembrane transport (GO:0055085)transmembrane transporter activity (GO:0022857)
Expression (TPM)
SLC7A6 — as a Regulated Gene

TFs regulating SLC7A6 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC7A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC7A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SLC7A6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC7A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:67,968,087–67,969,341 295.9 kb Distal (>10kb) Multiome 861
chr16:67,993,130–67,993,736 271.1 kb Distal (>10kb) Multiome 790
chr16:68,019,222–68,020,043 245.1 kb Distal (>10kb) Multiome 108
chr16:68,022,490–68,023,556 241.3 kb Distal (>10kb) Multiome 958
chr16:68,084,205–68,086,133 179.3 kb Distal (>10kb) Multiome 1092
chr16:68,235,016–68,238,254 28.4 kb Distal (>10kb) Multiome 1055
chr16:68,239,582–68,240,355 24.5 kb Distal (>10kb) Multiome 223
chr16:68,244,730–68,245,757 19.3 kb Distal (>10kb) Multiome 803
chr16:68,261,633–68,261,820 2.7 kb Proximal (<10kb) 294
chr16:68,264,033–68,265,087 73 bp At TSS Multiome 876
chr16:68,272,633–68,272,910 8.1 kb Proximal (<10kb) 41
chr16:68,310,451–68,311,505 46.5 kb Distal (>10kb) Multiome HiCAR 1061
chr16:68,328,654–68,329,423 64.2 kb Distal (>10kb) Multiome HiCAR 438
chr16:68,420,400–68,420,906 156.0 kb Distal (>10kb) Multiome 58
chr16:68,447,981–68,449,250 184.1 kb Distal (>10kb) Multiome 795
chr16:68,520,489–68,521,019 256.2 kb Distal (>10kb) Multiome 602
chr16:68,528,418–68,529,128 264.2 kb Distal (>10kb) Multiome 552
chr16:68,529,733–68,530,671 265.6 kb Distal (>10kb) Multiome 831
chr16:68,538,873–68,540,027 274.7 kb Distal (>10kb) Multiome 764

Genome Browser

Genomic view of the SLC7A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:67,958,087 – 68,550,027
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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