This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for SLC6A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC6A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC6A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:14,121,816–14,122,532 | 280.5 kb | Distal (>10kb) Multiome | 97 | |
| chr3:14,124,108–14,126,323 | 277.7 kb | Distal (>10kb) Multiome | 1032 | |
| chr3:14,178,020–14,179,126 | 223.9 kb | Distal (>10kb) Multiome | 960 | |
| chr3:14,216,206–14,216,677 | 186.2 kb | Distal (>10kb) Multiome | 226 | |
| chr3:14,232,409–14,233,221 | 169.8 kb | Distal (>10kb) Multiome | 527 | |
| chr3:14,272,392–14,272,931 | 129.8 kb | Distal (>10kb) Multiome | 132 | |
| chr3:14,319,426–14,320,088 | 82.8 kb | Distal (>10kb) Multiome | 332 | |
| chr3:14,401,899–14,403,672 | 97 bp | At TSS Multiome | 895 | |
| chr3:14,412,856–14,413,790 | 10.8 kb | Distal (>10kb) Multiome | 270 | |
| chr3:14,463,118–14,463,686 | 60.9 kb | Distal (>10kb) Multiome HiCAR | 134 | |
| chr3:14,508,941–14,509,537 | 106.5 kb | Distal (>10kb) Multiome | 235 | |
| chr3:14,532,598–14,533,121 | 130.2 kb | Distal (>10kb) Multiome | 210 | |
| chr3:14,601,718–14,603,350 | 200.4 kb | Distal (>10kb) Multiome | 282 | |
| chr3:14,651,173–14,652,219 | 249.0 kb | Distal (>10kb) Multiome | 942 |
Genomic view of the SLC6A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.