This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for SLC3A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC3A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC3A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:62,555,905–62,556,742 | 299.8 kb | Distal (>10kb) Multiome | 545 | |
| chr11:62,560,588–62,561,104 | 295.4 kb | Distal (>10kb) Multiome | 541 | |
| chr11:62,561,760–62,562,358 | 294.1 kb | Distal (>10kb) Multiome | 43 | |
| chr11:62,573,347–62,574,645 | 282.1 kb | Distal (>10kb) Multiome | 845 | |
| chr11:62,591,246–62,592,462 | 264.4 kb | Distal (>10kb) Multiome | 976 | |
| chr11:62,600,988–62,603,291 | 254.2 kb | Distal (>10kb) Multiome | 872 | |
| chr11:62,611,665–62,613,544 | 243.2 kb | Distal (>10kb) Multiome | 737 | |
| chr11:62,621,550–62,622,445 | 234.0 kb | Distal (>10kb) Multiome | 964 | |
| chr11:62,646,025–62,647,031 | 209.4 kb | Distal (>10kb) Multiome | 815 | |
| chr11:62,652,836–62,653,744 | 202.7 kb | Distal (>10kb) Multiome | 921 | |
| chr11:62,664,567–62,666,291 | 190.9 kb | Distal (>10kb) Multiome | 1020 | |
| chr11:62,671,328–62,672,522 | 184.3 kb | Distal (>10kb) Multiome | 882 | |
| chr11:62,705,543–62,707,930 | 149.8 kb | Distal (>10kb) Multiome | 760 | |
| chr11:62,708,691–62,710,293 | 146.5 kb | Distal (>10kb) Multiome | 531 | |
| chr11:62,726,557–62,728,947 | 128.5 kb | Distal (>10kb) Multiome | 1088 | |
| chr11:62,753,347–62,754,665 | 102.0 kb | Distal (>10kb) Multiome | 696 | |
| chr11:62,761,085–62,762,045 | 94.6 kb | Distal (>10kb) Multiome | 649 | |
| chr11:62,770,753–62,772,068 | 84.7 kb | Distal (>10kb) Multiome | 885 | |
| chr11:62,786,365–62,787,860 | 69.5 kb | Distal (>10kb) Multiome | 1073 | |
| chr11:62,791,569–62,792,385 | 64.1 kb | Distal (>10kb) Multiome | 805 | |
| chr11:62,804,451–62,807,080 | 50.6 kb | Distal (>10kb) Multiome | 994 | |
| chr11:62,831,037–62,832,904 | 24.1 kb | Distal (>10kb) Multiome | 870 | |
| chr11:62,839,042–62,842,743 | 14.7 kb | Distal (>10kb) Multiome | 1403 | |
| chr11:62,850,412–62,850,747 | 5.4 kb | Proximal (<10kb) | 137 | |
| chr11:62,851,028–62,851,955 | 4.6 kb | Proximal (<10kb) Multiome | 421 | |
| chr11:62,855,209–62,856,560 | 103 bp | At TSS Multiome | 1071 | |
| chr11:62,862,252–62,862,948 | 6.6 kb | Proximal (<10kb) Multiome | 360 | |
| chr11:62,880,343–62,881,977 | 24.8 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:62,909,033–62,909,985 | 53.3 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the SLC3A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.