This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for SLC39A14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC39A14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC39A14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:22,066,266–22,067,293 | 300.4 kb | Distal (>10kb) Multiome | 612 | |
| chr8:22,069,764–22,070,311 | 297.2 kb | Distal (>10kb) Multiome | 85 | |
| chr8:22,089,006–22,089,746 | 278.1 kb | Distal (>10kb) Multiome | 562 | |
| chr8:22,095,301–22,095,802 | 271.7 kb | Distal (>10kb) Multiome | 199 | |
| chr8:22,108,625–22,110,515 | 257.8 kb | Distal (>10kb) Multiome | 907 | |
| chr8:22,129,779–22,131,071 | 236.8 kb | Distal (>10kb) Multiome | 440 | |
| chr8:22,137,231–22,137,850 | 229.8 kb | Distal (>10kb) Multiome | 531 | |
| chr8:22,140,995–22,142,545 | 225.4 kb | Distal (>10kb) Multiome | 753 | |
| chr8:22,156,517–22,157,091 | 210.4 kb | Distal (>10kb) Multiome | 215 | |
| chr8:22,164,354–22,165,830 | 202.3 kb | Distal (>10kb) Multiome | 672 | |
| chr8:22,176,636–22,177,193 | 190.3 kb | Distal (>10kb) Multiome | 91 | |
| chr8:22,188,487–22,189,031 | 178.4 kb | Distal (>10kb) Multiome | 334 | |
| chr8:22,244,388–22,245,751 | 122.1 kb | Distal (>10kb) Multiome HiCAR | 1013 | |
| chr8:22,275,120–22,276,011 | 91.9 kb | Distal (>10kb) Multiome | 195 | |
| chr8:22,365,087–22,366,071 | 1.7 kb | Proximal (<10kb) Multiome | 444 | |
| chr8:22,366,173–22,366,706 | 570 bp | At TSS | 159 | |
| chr8:22,366,837–22,368,383 | 11 bp | At TSS Multiome | 859 | |
| chr8:22,440,466–22,441,769 | 73.8 kb | Distal (>10kb) Multiome | 784 | |
| chr8:22,548,856–22,550,046 | 182.3 kb | Distal (>10kb) Multiome | 539 | |
| chr8:22,551,208–22,552,929 | 184.3 kb | Distal (>10kb) Multiome | 406 | |
| chr8:22,561,173–22,562,479 | 194.6 kb | Distal (>10kb) Multiome | 678 | |
| chr8:22,565,061–22,566,429 | 198.5 kb | Distal (>10kb) Multiome | 404 | |
| chr8:22,574,221–22,574,708 | 207.2 kb | Distal (>10kb) Multiome | 527 | |
| chr8:22,578,724–22,579,696 | 211.9 kb | Distal (>10kb) Multiome | 404 | |
| chr8:22,588,723–22,589,902 | 222.0 kb | Distal (>10kb) Multiome | 612 | |
| chr8:22,594,681–22,595,713 | 228.0 kb | Distal (>10kb) Multiome | 402 | |
| chr8:22,597,003–22,600,290 | 230.2 kb | Distal (>10kb) Multiome | 889 | |
| chr8:22,604,300–22,605,436 | 237.5 kb | Distal (>10kb) Multiome | 1053 | |
| chr8:22,622,764–22,623,329 | 255.8 kb | Distal (>10kb) Multiome | 431 | |
| chr8:22,658,639–22,659,248 | 291.6 kb | Distal (>10kb) Multiome | 290 |
Genomic view of the SLC39A14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.