Enables xenobiotic transmembrane transporter activity. Involved in xenobiotic transmembrane transport. Located in endoplasmic reticulum membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC37A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC37A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC37A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:140,175,218–140,177,799 | 221.3 kb | Distal (>10kb) Multiome | 1056 | |
| chr7:140,229,607–140,231,952 | 168.4 kb | Distal (>10kb) Multiome | 914 | |
| chr7:140,241,793–140,243,015 | 156.3 kb | Distal (>10kb) Multiome | 460 | |
| chr7:140,278,313–140,279,187 | 119.7 kb | Distal (>10kb) Multiome | 65 | |
| chr7:140,397,976–140,398,715 | 11 bp | At TSS Multiome | 696 | |
| chr7:140,403,831–140,404,498 | 5.6 kb | Proximal (<10kb) Multiome | 333 | |
| chr7:140,455,562–140,456,050 | 57.4 kb | Distal (>10kb) Multiome | 50 | |
| chr7:140,478,495–140,480,078 | 81.0 kb | Distal (>10kb) Multiome | 869 | |
| chr7:140,481,148–140,482,022 | 83.1 kb | Distal (>10kb) Multiome | 15 | |
| chr7:140,488,120–140,488,789 | 90.0 kb | Distal (>10kb) Multiome | 230 | |
| chr7:140,517,960–140,518,418 | 119.7 kb | Distal (>10kb) Multiome | 472 | |
| chr7:140,541,306–140,541,982 | 143.3 kb | Distal (>10kb) Multiome | 422 | |
| chr7:140,639,882–140,641,732 | 242.3 kb | Distal (>10kb) Multiome | 486 | |
| chr7:140,672,673–140,674,052 | 274.5 kb | Distal (>10kb) Multiome | 648 | |
| chr7:140,696,318–140,697,705 | 298.3 kb | Distal (>10kb) Multiome | 1002 |
Genomic view of the SLC37A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.