This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for SLC36A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC36A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC36A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:151,157,085–151,158,664 | 289.8 kb | Distal (>10kb) Multiome | 760 | |
| chr5:151,223,077–151,224,282 | 223.6 kb | Distal (>10kb) Multiome | 662 | |
| chr5:151,252,199–151,253,942 | 194.7 kb | Distal (>10kb) Multiome | 746 | |
| chr5:151,348,447–151,349,638 | 98.6 kb | Distal (>10kb) Multiome | 138 | |
| chr5:151,405,271–151,406,618 | 42.0 kb | Distal (>10kb) Multiome | 175 | |
| chr5:151,447,360–151,448,441 | 1 bp | At TSS Multiome | 900 | |
| chr5:151,454,242–151,454,447 | 6.6 kb | Proximal (<10kb) | 109 | |
| chr5:151,496,053–151,496,694 | 48.7 kb | Distal (>10kb) Multiome | 64 | |
| chr5:151,500,606–151,501,090 | 53.3 kb | Distal (>10kb) Multiome | 332 | |
| chr5:151,590,936–151,591,543 | 143.7 kb | Distal (>10kb) Multiome | 83 | |
| chr5:151,658,968–151,659,631 | 211.5 kb | Distal (>10kb) Multiome | 335 | |
| chr5:151,673,039–151,674,114 | 225.9 kb | Distal (>10kb) Multiome | 193 | |
| chr5:151,684,706–151,685,487 | 237.4 kb | Distal (>10kb) Multiome | 323 | |
| chr5:151,686,404–151,687,445 | 239.4 kb | Distal (>10kb) Multiome | 314 | |
| chr5:151,740,170–151,741,128 | 293.0 kb | Distal (>10kb) Multiome | 315 |
Genomic view of the SLC36A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.