SLC26A6
solute carrier family 26 member 6 | DKFZp586E1422

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]

Developmental clusters: GC6
Biological processes 70 terms
PDZ domain binding (GO:0030165)angiotensin-activated signaling pathway (GO:0038166)apical plasma membrane (GO:0016324)apical plasma membrane (GO:0016324)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)bicarbonate transmembrane transporter activity (GO:0015106)bicarbonate transport (GO:0015701)bicarbonate transport (GO:0015701)bicarbonate transport (GO:0015701)brush border membrane (GO:0031526)cellular response to cAMP (GO:0071320)cellular response to fructose stimulus (GO:0071332)cellular response to type II interferon (GO:0071346)chloride transmembrane transport (GO:1902476)chloride transmembrane transport (GO:1902476)chloride transmembrane transporter activity (GO:0015108)chloride transport (GO:0006821)chloride transport (GO:0006821)chloride:bicarbonate antiporter activity (GO:0140900)chloride:bicarbonate antiporter activity (GO:0140900)cytoplasmic vesicle membrane (GO:0030659)efflux transmembrane transporter activity (GO:0015562)epithelial fluid transport (GO:0042045)estrous cycle (GO:0044849)formate transmembrane transporter activity (GO:0015499)formate transport (GO:0015724)identical protein binding (GO:0042802)intestinal absorption (GO:0050892)intracellular pH elevation (GO:0051454)mannitol transmembrane transport (GO:0015797)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)oxalate transmembrane transporter activity (GO:0019531)oxalate transmembrane transporter activity (GO:0019531)oxalate transport (GO:0019532)oxalate transport (GO:0019532)oxalate transport (GO:0019532)oxalic acid secretion (GO:0046724)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of dipeptide transmembrane transport (GO:2001150)protein binding (GO:0005515)protein kinase C signaling (GO:0070528)regulation of intracellular pH (GO:0051453)regulation of intracellular pH (GO:0051453)secondary active sulfate transmembrane transporter activity (GO:0008271)solute:inorganic anion antiporter activity (GO:0005452)solute:inorganic anion antiporter activity (GO:0005452)solute:inorganic anion antiporter activity (GO:0005452)solute:inorganic anion antiporter activity (GO:0005452)sperm capacitation (GO:0048240)sperm midpiece (GO:0097225)sulfate transmembrane transport (GO:1902358)sulfate transmembrane transport (GO:1902358)sulfate transmembrane transport (GO:1902358)sulfate transmembrane transport (GO:1902358)sulfate transmembrane transporter activity (GO:0015116)sulfate transmembrane transporter activity (GO:0015116)sulfate:bicarbonate antiporter activity (GO:0015383)transepithelial chloride transport (GO:0030321)transepithelial chloride transport (GO:0030321)transepithelial transport (GO:0070633)transmembrane transport (GO:0055085)transmembrane transport (GO:0055085)vesicle (GO:0031982)vesicle membrane (GO:0012506)
Expression (TPM)
SLC26A6 — as a Regulated Gene

TFs regulating SLC26A6 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC26A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC26A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SLC26A6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC26A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr3:48,372,864–48,373,543 262.2 kb Distal (>10kb) Multiome 49
chr3:48,428,528–48,430,504 205.4 kb Distal (>10kb) Multiome 910
chr3:48,439,801–48,440,548 195.3 kb Distal (>10kb) Multiome 787
chr3:48,446,396–48,447,180 188.7 kb Distal (>10kb) Multiome 767
chr3:48,465,344–48,466,310 169.7 kb Distal (>10kb) Multiome 670
chr3:48,472,636–48,473,658 162.2 kb Distal (>10kb) Multiome 821
chr3:48,503,451–48,504,839 131.4 kb Distal (>10kb) Multiome 419
chr3:48,556,022–48,557,666 78.4 kb Distal (>10kb) Multiome 794
chr3:48,558,131–48,558,793 77.1 kb Distal (>10kb) Multiome 503
chr3:48,608,816–48,610,628 25.8 kb Distal (>10kb) Multiome 850
chr3:48,634,696–48,636,251 114 bp At TSS Multiome 898
chr3:48,655,787–48,657,257 21.0 kb Distal (>10kb) Multiome 438
chr3:48,661,275–48,664,636 26.3 kb Distal (>10kb) Multiome 1248
chr3:48,685,362–48,686,531 50.4 kb Distal (>10kb) Multiome 770
chr3:48,716,958–48,717,863 81.9 kb Distal (>10kb) Multiome 634
chr3:48,847,059–48,848,224 212.3 kb Distal (>10kb) Multiome 772
chr3:48,898,423–48,899,110 263.4 kb Distal (>10kb) Multiome 739
chr3:48,918,234–48,919,609 283.3 kb Distal (>10kb) Multiome 877

Genome Browser

Genomic view of the SLC26A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr3:48,362,864 – 48,929,609
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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