This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for SLC26A11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC26A11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC26A11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:79,924,070–79,924,677 | 296.1 kb | Distal (>10kb) Multiome | 279 | |
| chr17:79,926,061–79,926,673 | 294.1 kb | Distal (>10kb) Multiome | 366 | |
| chr17:79,991,451–79,992,302 | 228.7 kb | Distal (>10kb) Multiome | 655 | |
| chr17:80,008,356–80,008,965 | 211.8 kb | Distal (>10kb) Multiome | 554 | |
| chr17:80,035,332–80,037,314 | 183.6 kb | Distal (>10kb) Multiome | 852 | |
| chr17:80,101,092–80,102,236 | 119.0 kb | Distal (>10kb) Multiome | 851 | |
| chr17:80,146,527–80,148,008 | 73.2 kb | Distal (>10kb) Multiome | 955 | |
| chr17:80,219,620–80,221,064 | 24 bp | At TSS Multiome | 809 | |
| chr17:80,260,016–80,260,559 | 39.9 kb | Distal (>10kb) Multiome | 677 | |
| chr17:80,260,789–80,261,746 | 41.1 kb | Distal (>10kb) Multiome | 896 | |
| chr17:80,308,064–80,309,516 | 87.9 kb | Distal (>10kb) Multiome | 193 | |
| chr17:80,376,366–80,377,013 | 156.2 kb | Distal (>10kb) Multiome | 75 | |
| chr17:80,407,766–80,408,220 | 187.5 kb | Distal (>10kb) Multiome | 12 | |
| chr17:80,414,488–80,415,786 | 194.8 kb | Distal (>10kb) Multiome | 964 | |
| chr17:80,426,748–80,427,205 | 206.6 kb | Distal (>10kb) Multiome | 529 | |
| chr17:80,454,454–80,455,448 | 234.4 kb | Distal (>10kb) Multiome | 1002 | |
| chr17:80,475,705–80,477,431 | 256.1 kb | Distal (>10kb) Multiome | 345 | |
| chr17:80,477,689–80,478,296 | 257.8 kb | Distal (>10kb) Multiome | 240 |
Genomic view of the SLC26A11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.