Enables pyrimidine nucleotide transmembrane transporter activity. Involved in mitochondrial genome maintenance; pyrimidine nucleotide transport; and regulation of mitochondrial membrane potential. Located in mitochondrion. Implicated in familial hyperinsulinemic hypoglycemia 8. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC25A36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:140,781,182–140,782,296 | 159.9 kb | Distal (>10kb) Multiome | 77 | |
| chr3:140,822,781–140,823,440 | 118.6 kb | Distal (>10kb) Multiome | 55 | |
| chr3:140,856,772–140,857,511 | 84.7 kb | Distal (>10kb) Multiome | 137 | |
| chr3:140,941,304–140,943,041 | 1.0 kb | Proximal (<10kb) Multiome | 1087 | |
| chr3:141,050,639–141,052,361 | 109.5 kb | Distal (>10kb) Multiome | 469 | |
| chr3:141,070,840–141,071,438 | 129.3 kb | Distal (>10kb) Multiome | 164 | |
| chr3:141,074,501–141,074,972 | 132.9 kb | Distal (>10kb) Multiome | 69 | |
| chr3:141,231,050–141,232,888 | 289.9 kb | Distal (>10kb) Multiome | 693 |
Genomic view of the SLC25A36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.