This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for SLC1A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC1A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC1A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:36,590,574–36,590,890 | 5.7 kb | Proximal (<10kb) | 62 | |
| chr5:36,596,123–36,596,706 | 109 bp | At TSS Multiome | 93 | |
| chr5:36,602,828–36,603,404 | 6.2 kb | Proximal (<10kb) | 99 | |
| chr5:36,606,440–36,607,386 | 10.0 kb | Distal (>10kb) Multiome | 471 | |
| chr5:36,607,999–36,608,339 | 1.4 kb | Proximal (<10kb) | 100 | |
| chr5:36,614,473–36,614,638 | 7.9 kb | Proximal (<10kb) | 43 | |
| chr5:36,618,961–36,619,487 | 22.6 kb | Distal (>10kb) Multiome | 147 | |
| chr5:36,689,905–36,690,922 | 93.8 kb | Distal (>10kb) Multiome HiCAR | 674 | |
| chr5:36,692,732–36,693,630 | 96.6 kb | Distal (>10kb) Multiome HiCAR | 332 | |
| chr5:36,744,113–36,746,060 | 148.1 kb | Distal (>10kb) Multiome | 801 | |
| chr5:36,875,838–36,877,715 | 280.2 kb | Distal (>10kb) Multiome | 929 |
Genomic view of the SLC1A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.