SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for SLC16A10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC16A10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC16A10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:110,814,145–110,816,325 | 271.8 kb | Distal (>10kb) Multiome | 1024 | |
| chr6:110,873,984–110,876,719 | 211.2 kb | Distal (>10kb) Multiome | 1070 | |
| chr6:110,958,321–110,959,190 | 128.8 kb | Distal (>10kb) Multiome | 984 | |
| chr6:110,981,592–110,982,485 | 105.5 kb | Distal (>10kb) Multiome | 968 | |
| chr6:111,033,760–111,034,293 | 53.5 kb | Distal (>10kb) Multiome | 47 | |
| chr6:111,087,119–111,088,655 | 19 bp | At TSS Multiome | 637 | |
| chr6:111,091,616–111,092,325 | 4.4 kb | Proximal (<10kb) Multiome | 90 | |
| chr6:111,251,962–111,252,726 | 164.7 kb | Distal (>10kb) Multiome | 110 | |
| chr6:111,258,884–111,259,808 | 171.8 kb | Distal (>10kb) Multiome | 945 |
Genomic view of the SLC16A10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.