This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SF3B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SF3B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SF3B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,779,808–65,781,988 | 272.3 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 263.9 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 234.1 kb | Distal (>10kb) Multiome | 694 | |
| chr11:65,833,325–65,834,189 | 218.6 kb | Distal (>10kb) Multiome | 396 | |
| chr11:65,856,804–65,858,748 | 195.3 kb | Distal (>10kb) Multiome | 972 | |
| chr11:65,859,034–65,861,240 | 191.7 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:65,871,920–65,874,072 | 178.7 kb | Distal (>10kb) Multiome | 741 | |
| chr11:65,887,987–65,889,162 | 163.8 kb | Distal (>10kb) Multiome | 824 | |
| chr11:65,890,253–65,891,457 | 161.7 kb | Distal (>10kb) Multiome | 895 | |
| chr11:65,899,867–65,900,779 | 151.8 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,918,507–65,920,266 | 133.1 kb | Distal (>10kb) Multiome | 992 | |
| chr11:65,961,271–65,962,172 | 90.7 kb | Distal (>10kb) Multiome | 834 | |
| chr11:66,001,882–66,002,962 | 50.0 kb | Distal (>10kb) Multiome | 1022 | |
| chr11:66,007,227–66,007,703 | 44.9 kb | Distal (>10kb) Multiome | 100 | |
| chr11:66,022,341–66,022,903 | 29.8 kb | Distal (>10kb) Multiome | 466 | |
| chr11:66,045,170–66,045,637 | 7.0 kb | Proximal (<10kb) Multiome | 394 | |
| chr11:66,048,912–66,049,460 | 3.2 kb | Proximal (<10kb) Multiome | 83 | |
| chr11:66,051,716–66,052,760 | 173 bp | At TSS Multiome | 901 | |
| chr11:66,068,281–66,068,499 | 7.6 kb | Proximal (<10kb) | 252 | |
| chr11:66,069,690–66,071,102 | 17.8 kb | Distal (>10kb) Multiome | 622 | |
| chr11:66,256,991–66,258,893 | 205.6 kb | Distal (>10kb) Multiome | 844 | |
| chr11:66,266,650–66,269,501 | 215.2 kb | Distal (>10kb) Multiome | 869 | |
| chr11:66,277,646–66,278,447 | 225.7 kb | Distal (>10kb) Multiome | 363 | |
| chr11:66,282,288–66,283,017 | 230.2 kb | Distal (>10kb) Multiome | 618 | |
| chr11:66,288,772–66,289,992 | 237.0 kb | Distal (>10kb) Multiome | 944 | |
| chr11:66,311,658–66,313,958 | 259.8 kb | Distal (>10kb) Multiome | 1005 | |
| chr11:66,316,861–66,317,347 | 264.7 kb | Distal (>10kb) Multiome | 164 | |
| chr11:66,328,223–66,328,781 | 276.2 kb | Distal (>10kb) Multiome | 662 | |
| chr11:66,344,804–66,345,488 | 292.8 kb | Distal (>10kb) Multiome | 731 | |
| chr11:66,347,078–66,348,463 | 295.4 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the SF3B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.