SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009]
Transcription factors with Perturb-seq knockdown data for SEPTIN11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEPTIN11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEPTIN11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:76,689,137–76,689,934 | 260.3 kb | Distal (>10kb) Multiome | 423 | |
| chr4:76,696,194–76,696,677 | 253.4 kb | Distal (>10kb) Multiome | 141 | |
| chr4:76,801,591–76,802,890 | 147.8 kb | Distal (>10kb) Multiome | 200 | |
| chr4:76,867,647–76,869,012 | 81.4 kb | Distal (>10kb) Multiome | 115 | |
| chr4:76,896,697–76,898,709 | 51.6 kb | Distal (>10kb) Multiome | 498 | |
| chr4:76,948,267–76,951,238 | 759 bp | At TSS Multiome | 968 | |
| chr4:77,012,534–77,013,096 | 63.0 kb | Distal (>10kb) Multiome | 56 | |
| chr4:77,074,968–77,076,780 | 126.5 kb | Distal (>10kb) Multiome | 1071 | |
| chr4:77,084,016–77,084,805 | 134.6 kb | Distal (>10kb) Multiome | 93 | |
| chr4:77,123,593–77,124,378 | 174.2 kb | Distal (>10kb) Multiome | 24 | |
| chr4:77,128,136–77,129,079 | 178.8 kb | Distal (>10kb) Multiome | 73 | |
| chr4:77,156,523–77,158,721 | 208.5 kb | Distal (>10kb) Multiome | 1039 | |
| chr4:77,175,021–77,175,714 | 225.7 kb | Distal (>10kb) Multiome | 259 | |
| chr4:77,193,476–77,193,939 | 243.9 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the SEPTIN11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.