The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Transcription factors with Perturb-seq knockdown data for SENP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SENP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SENP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:101,255,263–101,256,022 | 257.5 kb | Distal (>10kb) Multiome | 116 | |
| chr3:101,466,683–101,467,491 | 46.1 kb | Distal (>10kb) Multiome | 289 | |
| chr3:101,512,475–101,513,632 | 92 bp | At TSS Multiome | 799 | |
| chr3:101,518,457–101,518,658 | 5.3 kb | Proximal (<10kb) | 150 | |
| chr3:101,530,192–101,530,904 | 17.4 kb | Distal (>10kb) Multiome | 336 | |
| chr3:101,561,343–101,562,162 | 48.7 kb | Distal (>10kb) Multiome | 783 | |
| chr3:101,573,305–101,575,121 | 60.9 kb | Distal (>10kb) Multiome | 1039 | |
| chr3:101,641,500–101,642,206 | 128.6 kb | Distal (>10kb) Multiome | 397 | |
| chr3:101,724,220–101,725,851 | 211.6 kb | Distal (>10kb) Multiome | 749 | |
| chr3:101,778,676–101,779,992 | 266.1 kb | Distal (>10kb) Multiome | 826 |
Genomic view of the SENP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.