The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SEC24C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC24C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC24C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,495,235–73,496,398 | 248.5 kb | Distal (>10kb) Multiome | 908 | |
| chr10:73,591,236–73,591,781 | 152.9 kb | Distal (>10kb) Multiome | 359 | |
| chr10:73,591,961–73,592,227 | 152.3 kb | Distal (>10kb) Multiome | 458 | |
| chr10:73,625,111–73,626,369 | 118.4 kb | Distal (>10kb) Multiome | 810 | |
| chr10:73,647,157–73,648,042 | 96.9 kb | Distal (>10kb) Multiome | 238 | |
| chr10:73,730,165–73,730,854 | 13.9 kb | Distal (>10kb) Multiome | 823 | |
| chr10:73,741,689–73,742,673 | 2.2 kb | Proximal (<10kb) Multiome | 190 | |
| chr10:73,743,801–73,744,894 | 27 bp | At TSS Multiome | 962 | |
| chr10:73,771,782–73,773,237 | 28.4 kb | Distal (>10kb) Multiome | 918 | |
| chr10:73,781,688–73,782,352 | 37.7 kb | Distal (>10kb) Multiome | 721 | |
| chr10:73,785,180–73,785,869 | 41.1 kb | Distal (>10kb) Multiome | 745 | |
| chr10:73,810,828–73,812,285 | 67.5 kb | Distal (>10kb) Multiome | 876 | |
| chr10:73,817,045–73,817,772 | 73.0 kb | Distal (>10kb) Multiome | 123 | |
| chr10:73,823,062–73,824,101 | 79.2 kb | Distal (>10kb) Multiome | 130 | |
| chr10:73,873,847–73,875,246 | 130.3 kb | Distal (>10kb) Multiome | 654 | |
| chr10:73,906,669–73,907,201 | 162.5 kb | Distal (>10kb) Multiome | 417 | |
| chr10:73,910,388–73,911,812 | 166.7 kb | Distal (>10kb) Multiome | 486 | |
| chr10:73,965,730–73,966,725 | 221.9 kb | Distal (>10kb) Multiome | 552 | |
| chr10:73,994,650–73,995,392 | 250.8 kb | Distal (>10kb) Multiome | 69 | |
| chr10:73,997,294–73,999,626 | 253.5 kb | Distal (>10kb) Multiome | 964 |
Genomic view of the SEC24C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.