The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for SEC24B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC24B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC24B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:109,301,583–109,303,714 | 130.9 kb | Distal (>10kb) Multiome | 426 | |
| chr4:109,375,427–109,376,315 | 57.9 kb | Distal (>10kb) Multiome | 86 | |
| chr4:109,386,823–109,387,310 | 46.8 kb | Distal (>10kb) Multiome | 74 | |
| chr4:109,419,054–109,420,658 | 14.0 kb | Distal (>10kb) Multiome | 227 | |
| chr4:109,433,232–109,434,512 | 98 bp | At TSS Multiome | 802 | |
| chr4:109,435,869–109,436,805 | 2.1 kb | Proximal (<10kb) | 99 | |
| chr4:109,559,632–109,561,390 | 126.3 kb | Distal (>10kb) Multiome | 756 | |
| chr4:109,701,412–109,703,899 | 269.6 kb | Distal (>10kb) Multiome | 799 | |
| chr4:109,729,247–109,730,761 | 296.3 kb | Distal (>10kb) Multiome | 793 | |
| chr4:109,814,867–109,816,081 | 381.7 kb | Distal (>10kb) Multiome HiCAR | 846 |
Genomic view of the SEC24B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.