Enables serine-type endopeptidase activity. Involved in signal peptide processing. Located in endoplasmic reticulum membrane. Part of signal peptidase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SEC11C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC11C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC11C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:58,846,800–58,849,106 | 292.0 kb | Distal (>10kb) Multiome | 416 | |
| chr18:58,863,566–58,864,932 | 275.5 kb | Distal (>10kb) Multiome | 286 | |
| chr18:58,867,169–58,867,750 | 272.4 kb | Distal (>10kb) Multiome | 136 | |
| chr18:59,001,173–59,002,098 | 138.4 kb | Distal (>10kb) Multiome | 76 | |
| chr18:59,139,305–59,140,740 | 144 bp | At TSS Multiome | 767 | |
| chr18:59,176,733–59,177,291 | 37.1 kb | Distal (>10kb) Multiome | 9 | |
| chr18:59,219,767–59,220,751 | 80.4 kb | Distal (>10kb) Multiome | 135 | |
| chr18:59,265,207–59,265,918 | 125.7 kb | Distal (>10kb) Multiome | 139 | |
| chr18:59,268,665–59,269,734 | 129.4 kb | Distal (>10kb) Multiome | 312 | |
| chr18:59,272,354–59,274,393 | 133.6 kb | Distal (>10kb) Multiome | 271 | |
| chr18:59,308,314–59,309,013 | 168.8 kb | Distal (>10kb) Multiome | 405 | |
| chr18:59,358,405–59,359,814 | 219.5 kb | Distal (>10kb) Multiome | 877 | |
| chr18:59,386,497–59,387,519 | 247.2 kb | Distal (>10kb) Multiome | 118 | |
| chr18:59,402,363–59,402,995 | 262.7 kb | Distal (>10kb) Multiome | 491 | |
| chr18:59,416,052–59,417,110 | 276.6 kb | Distal (>10kb) Multiome | 123 |
Genomic view of the SEC11C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.