Predicted to enable nucleic acid binding activity. Involved in positive regulation of cell cycle and positive regulation of epithelial cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SCAND3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCAND3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCAND3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:28,335,073–28,336,704 | 251.5 kb | Distal (>10kb) Multiome | 1036 | |
| chr6:28,349,817–28,350,289 | 237.3 kb | Distal (>10kb) Multiome | 884 | |
| chr6:28,356,177–28,356,613 | 231.0 kb | Distal (>10kb) Multiome | 569 | |
| chr6:28,383,266–28,383,869 | 203.7 kb | Distal (>10kb) Multiome | 821 | |
| chr6:28,399,292–28,400,183 | 187.5 kb | Distal (>10kb) Multiome | 978 | |
| chr6:28,443,132–28,443,643 | 143.9 kb | Distal (>10kb) Multiome | 481 | |
| chr6:28,468,726–28,469,991 | 118.0 kb | Distal (>10kb) Multiome | 36 | |
| chr6:28,542,393–28,543,473 | 44.5 kb | Distal (>10kb) Multiome | 775 | |
| chr6:28,583,617–28,583,855 | 3.4 kb | Proximal (<10kb) | 35 | |
| chr6:28,587,026–28,587,675 | 60 bp | At TSS Multiome | 777 | |
| chr6:28,589,233–28,589,816 | 2.2 kb | Proximal (<10kb) Multiome | 684 | |
| chr6:28,597,260–28,597,444 | 10.0 kb | Proximal (<10kb) | 319 | |
| chr6:28,657,863–28,658,336 | 70.8 kb | Distal (>10kb) Multiome | 477 | |
| chr6:28,682,403–28,683,572 | 95.5 kb | Distal (>10kb) Multiome | 119 | |
| chr6:28,709,835–28,710,861 | 122.9 kb | Distal (>10kb) Multiome | 486 | |
| chr6:28,758,091–28,758,572 | 171.0 kb | Distal (>10kb) Multiome | 538 | |
| chr6:28,766,057–28,766,737 | 179.2 kb | Distal (>10kb) Multiome | 45 | |
| chr6:28,775,686–28,777,151 | 189.2 kb | Distal (>10kb) Multiome | 330 | |
| chr6:28,789,668–28,790,123 | 202.6 kb | Distal (>10kb) Multiome | 466 | |
| chr6:28,795,706–28,796,323 | 208.8 kb | Distal (>10kb) Multiome | 598 | |
| chr6:28,837,417–28,839,268 | 251.6 kb | Distal (>10kb) Multiome | 927 | |
| chr6:28,863,417–28,864,476 | 276.6 kb | Distal (>10kb) Multiome | 894 | |
| chr6:28,865,612–28,867,050 | 279.1 kb | Distal (>10kb) Multiome | 785 |
Genomic view of the SCAND3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.