Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and retinal rod cell development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SAMD11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAMD11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAMD11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:904,256–904,920 | 35.6 kb | Distal (>10kb) Multiome | 590 | |
| chr1:921,105–921,374 | 2.5 kb | Proximal (<10kb) | 577 | |
| chr1:923,612–925,339 | 16.5 kb | Distal (>10kb) Multiome | 500 | |
| chr1:925,528–925,948 | 1.6 kb | Proximal (<10kb) | 254 | |
| chr1:935,824–936,223 | 4.1 kb | Proximal (<10kb) | 241 | |
| chr1:939,835–943,080 | 1.6 kb | Proximal (<10kb) Multiome | 864 | |
| chr1:959,035–960,017 | 19.0 kb | Distal (>10kb) Multiome | 622 | |
| chr1:960,291–961,429 | 20.4 kb | Distal (>10kb) Multiome | 552 | |
| chr1:975,960–976,521 | 35.9 kb | Distal (>10kb) Multiome | 476 | |
| chr1:998,350–1,000,999 | 60.0 kb | Distal (>10kb) Multiome | 1047 | |
| chr1:1,001,349–1,002,099 | 61.7 kb | Distal (>10kb) Multiome | 646 | |
| chr1:1,005,015–1,005,702 | 64.9 kb | Distal (>10kb) Multiome | 532 | |
| chr1:1,019,142–1,021,414 | 79.3 kb | Distal (>10kb) Multiome | 707 | |
| chr1:1,032,438–1,034,753 | 92.9 kb | Distal (>10kb) Multiome | 475 | |
| chr1:1,040,071–1,041,597 | 100.6 kb | Distal (>10kb) Multiome | 410 | |
| chr1:1,058,856–1,060,114 | 119.2 kb | Distal (>10kb) Multiome | 609 | |
| chr1:1,068,556–1,069,991 | 128.9 kb | Distal (>10kb) Multiome | 577 | |
| chr1:1,079,478–1,080,558 | 139.7 kb | Distal (>10kb) Multiome | 746 | |
| chr1:1,115,769–1,117,022 | 175.9 kb | Distal (>10kb) Multiome | 743 | |
| chr1:1,157,424–1,158,362 | 217.2 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,200,907–1,201,739 | 261.1 kb | Distal (>10kb) Multiome | 430 | |
| chr1:1,231,448–1,233,390 | 291.8 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the SAMD11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.