This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RSU1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RSU1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RSU1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:15,802,138–15,802,908 | 1014.9 kb | Distal (>10kb) Multiome HiCAR | 244 | |
| chr10:15,856,555–15,857,325 | 960.5 kb | Distal (>10kb) Multiome HiCAR | 264 | |
| chr10:15,859,871–15,860,810 | 957.0 kb | Distal (>10kb) Multiome HiCAR | 695 | |
| chr10:16,558,869–16,559,824 | 258.1 kb | Distal (>10kb) Multiome | 57 | |
| chr10:16,765,187–16,766,242 | 51.7 kb | Distal (>10kb) Multiome | 148 | |
| chr10:16,809,398–16,809,594 | 7.8 kb | Proximal (<10kb) | 90 | |
| chr10:16,816,770–16,818,262 | 133 bp | At TSS Multiome | 801 | |
| chr10:16,891,324–16,892,326 | 74.2 kb | Distal (>10kb) Multiome | 599 | |
| chr10:16,962,424–16,962,891 | 145.2 kb | Distal (>10kb) Multiome | 31 | |
| chr10:17,387,758–17,388,950 | 570.9 kb | Distal (>10kb) Multiome HiCAR | 319 | |
| chr10:18,251,621–18,252,499 | 1434.6 kb | Distal (>10kb) Multiome HiCAR | 125 |
Genomic view of the RSU1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.