This gene encodes a glycoprotein that contains a RING-type zinc finger domain and an SPRY domain of unknown function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for RSPRY1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RSPRY1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RSPRY1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:56,931,455–56,933,141 | 254.2 kb | Distal (>10kb) Multiome | 1047 | |
| chr16:56,989,388–56,989,907 | 196.8 kb | Distal (>10kb) Multiome | 646 | |
| chr16:57,092,097–57,093,443 | 93.6 kb | Distal (>10kb) Multiome | 584 | |
| chr16:57,178,760–57,179,163 | 7.1 kb | Proximal (<10kb) | 78 | |
| chr16:57,185,577–57,186,853 | 115 bp | At TSS Multiome | 925 | |
| chr16:57,187,158–57,187,545 | 852 bp | At TSS | 351 | |
| chr16:57,244,660–57,245,782 | 58.8 kb | Distal (>10kb) Multiome | 949 | |
| chr16:57,256,968–57,257,582 | 70.9 kb | Distal (>10kb) Multiome | 94 | |
| chr16:57,284,181–57,285,057 | 98.4 kb | Distal (>10kb) Multiome | 883 | |
| chr16:57,299,458–57,301,365 | 113.7 kb | Distal (>10kb) Multiome | 1112 | |
| chr16:57,416,668–57,417,660 | 230.9 kb | Distal (>10kb) Multiome | 597 | |
| chr16:57,427,202–57,428,139 | 241.3 kb | Distal (>10kb) Multiome | 105 | |
| chr16:57,446,894–57,447,991 | 261.1 kb | Distal (>10kb) Multiome | 958 | |
| chr16:57,462,496–57,462,948 | 276.4 kb | Distal (>10kb) Multiome | 903 | |
| chr16:57,475,764–57,476,257 | 289.7 kb | Distal (>10kb) Multiome | 391 | |
| chr16:57,485,922–57,486,831 | 300.2 kb | Distal (>10kb) Multiome | 527 |
Genomic view of the RSPRY1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.