Predicted to enable histone H4K20 demethylase activity and metal ion binding activity. Predicted to be involved in chromatin remodeling. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RSBN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RSBN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RSBN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:113,758,781–113,760,075 | 52.8 kb | Distal (>10kb) Multiome | 889 | |
| chr1:113,811,244–113,812,738 | 130 bp | At TSS Multiome | 978 | |
| chr1:113,812,886–113,813,034 | 593 bp | At TSS | 208 | |
| chr1:113,904,394–113,905,850 | 92.8 kb | Distal (>10kb) Multiome | 1025 | |
| chr1:113,929,054–113,930,528 | 117.3 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:113,938,331–113,938,852 | 126.3 kb | Distal (>10kb) Multiome | 26 | |
| chr1:113,978,866–113,979,713 | 167.0 kb | Distal (>10kb) Multiome | 426 | |
| chr1:113,999,654–114,000,118 | 187.6 kb | Distal (>10kb) Multiome | 40 | |
| chr1:114,031,872–114,032,790 | 220.0 kb | Distal (>10kb) Multiome | 88 | |
| chr1:114,037,114–114,037,804 | 225.0 kb | Distal (>10kb) Multiome | 57 | |
| chr1:114,080,406–114,081,350 | 268.4 kb | Distal (>10kb) Multiome | 200 |
Genomic view of the RSBN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.