This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for RRAS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRAS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRAS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:14,075,211–14,076,080 | 283.5 kb | Distal (>10kb) Multiome | 190 | |
| chr11:14,340,767–14,341,038 | 1.1 kb | Proximal (<10kb) | 57 | |
| chr11:14,350,233–14,350,559 | 8.1 kb | Proximal (<10kb) | 90 | |
| chr11:14,357,756–14,359,493 | 144 bp | At TSS Multiome | 664 | |
| chr11:14,380,905–14,381,570 | 22.1 kb | Distal (>10kb) Multiome | 501 | |
| chr11:14,499,208–14,500,395 | 140.7 kb | Distal (>10kb) Multiome | 813 | |
| chr11:14,519,723–14,521,072 | 161.3 kb | Distal (>10kb) Multiome | 1010 | |
| chr11:14,643,085–14,645,138 | 284.7 kb | Distal (>10kb) Multiome | 880 |
Genomic view of the RRAS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.