Enables 5S rRNA binding activity. Involved in protein localization to nucleolus; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RPF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:110,511,262–110,512,278 | 470.4 kb | Distal (>10kb) Multiome HiCAR | 164 | |
| chr6:110,618,379–110,619,138 | 363.2 kb | Distal (>10kb) Multiome HiCAR | 186 | |
| chr6:110,786,496–110,787,137 | 195.2 kb | Distal (>10kb) Multiome | 18 | |
| chr6:110,814,145–110,816,325 | 166.4 kb | Distal (>10kb) Multiome | 1024 | |
| chr6:110,873,984–110,876,719 | 105.7 kb | Distal (>10kb) Multiome | 1070 | |
| chr6:110,958,321–110,959,190 | 23.3 kb | Distal (>10kb) Multiome | 984 | |
| chr6:110,981,592–110,982,485 | 25 bp | At TSS Multiome | 968 | |
| chr6:111,033,760–111,034,293 | 52.0 kb | Distal (>10kb) Multiome | 47 | |
| chr6:111,087,119–111,088,655 | 105.4 kb | Distal (>10kb) Multiome | 637 | |
| chr6:111,091,616–111,092,325 | 109.8 kb | Distal (>10kb) Multiome | 90 | |
| chr6:111,251,962–111,252,726 | 270.2 kb | Distal (>10kb) Multiome | 110 | |
| chr6:111,258,884–111,259,808 | 277.2 kb | Distal (>10kb) Multiome | 945 |
Genomic view of the RPF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.