The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ROR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ROR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ROR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:91,714,355–91,714,808 | 235.6 kb | Distal (>10kb) Multiome | 186 | |
| chr9:91,721,275–91,721,895 | 228.8 kb | Distal (>10kb) Multiome | 91 | |
| chr9:91,886,525–91,887,118 | 63.5 kb | Distal (>10kb) Multiome | 127 | |
| chr9:91,899,016–91,900,833 | 49.9 kb | Distal (>10kb) Multiome | 545 | |
| chr9:91,907,557–91,908,633 | 42.1 kb | Distal (>10kb) Multiome | 400 | |
| chr9:91,939,791–91,941,167 | 10.0 kb | Distal (>10kb) Multiome | 168 | |
| chr9:91,945,246–91,945,588 | 4.6 kb | Proximal (<10kb) | 210 | |
| chr9:91,946,111–91,946,528 | 3.7 kb | Proximal (<10kb) | 59 | |
| chr9:91,948,140–91,949,358 | 1.4 kb | Proximal (<10kb) Multiome | 449 | |
| chr9:91,949,582–91,950,808 | 119 bp | At TSS Multiome | 453 | |
| chr9:91,952,242–91,952,784 | 2.0 kb | Proximal (<10kb) | 40 | |
| chr9:91,953,772–91,954,026 | 3.5 kb | Proximal (<10kb) | 21 | |
| chr9:91,954,829–91,955,056 | 4.6 kb | Proximal (<10kb) | 143 | |
| chr9:91,994,245–91,995,301 | 44.4 kb | Distal (>10kb) Multiome | 243 | |
| chr9:92,114,946–92,115,785 | 165.2 kb | Distal (>10kb) Multiome | 807 | |
| chr9:92,133,789–92,134,516 | 183.9 kb | Distal (>10kb) Multiome | 252 | |
| chr9:92,137,993–92,138,553 | 188.0 kb | Distal (>10kb) Multiome | 237 | |
| chr9:92,140,183–92,140,786 | 190.2 kb | Distal (>10kb) Multiome | 418 |
Genomic view of the ROR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.