Transcription factors with Perturb-seq knockdown data for RNF213-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF213-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF213-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:80,146,527–80,148,008 | 267.9 kb | Distal (>10kb) Multiome | 955 | |
| chr17:80,219,620–80,221,064 | 194.7 kb | Distal (>10kb) Multiome | 809 | |
| chr17:80,260,016–80,260,559 | 154.8 kb | Distal (>10kb) Multiome | 677 | |
| chr17:80,260,789–80,261,746 | 153.6 kb | Distal (>10kb) Multiome | 896 | |
| chr17:80,308,064–80,309,516 | 106.8 kb | Distal (>10kb) Multiome | 193 | |
| chr17:80,376,366–80,377,013 | 38.5 kb | Distal (>10kb) Multiome | 75 | |
| chr17:80,407,766–80,408,220 | 7.2 kb | Proximal (<10kb) Multiome | 12 | |
| chr17:80,408,818–80,409,120 | 6.0 kb | Proximal (<10kb) | 17 | |
| chr17:80,414,488–80,415,786 | 141 bp | At TSS Multiome | 964 | |
| chr17:80,426,748–80,427,205 | 11.9 kb | Distal (>10kb) Multiome | 529 | |
| chr17:80,454,454–80,455,448 | 39.7 kb | Distal (>10kb) Multiome | 1002 | |
| chr17:80,475,705–80,477,431 | 61.4 kb | Distal (>10kb) Multiome | 345 | |
| chr17:80,477,689–80,478,296 | 63.1 kb | Distal (>10kb) Multiome | 240 | |
| chr17:80,544,698–80,545,445 | 129.7 kb | Distal (>10kb) Multiome | 934 | |
| chr17:80,621,758–80,622,265 | 206.8 kb | Distal (>10kb) Multiome | 97 | |
| chr17:80,833,089–80,833,581 | 418.2 kb | Distal (>10kb) Multiome HiCAR | 572 | |
| chr17:80,981,166–80,981,777 | 566.3 kb | Distal (>10kb) Multiome HiCAR | 249 |
Genomic view of the RNF213-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.