Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RFPL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RFPL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RFPL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:31,943,414–31,945,454 | 260.7 kb | Distal (>10kb) Multiome | 807 | |
| chr22:31,969,969–31,971,124 | 234.5 kb | Distal (>10kb) Multiome | 601 | |
| chr22:32,139,785–32,140,267 | 65.0 kb | Distal (>10kb) Multiome | 14 | |
| chr22:32,175,754–32,176,273 | 29.0 kb | Distal (>10kb) Multiome | 106 | |
| chr22:32,202,214–32,203,260 | 2.6 kb | Proximal (<10kb) Multiome | 251 | |
| chr22:32,204,184–32,205,469 | 62 bp | At TSS Multiome | 338 | |
| chr22:32,206,463–32,207,219 | 1.9 kb | Proximal (<10kb) Multiome | 136 | |
| chr22:32,474,361–32,475,480 | 269.7 kb | Distal (>10kb) Multiome | 819 | |
| chr22:32,502,334–32,503,331 | 297.7 kb | Distal (>10kb) Multiome | 63 |
Genomic view of the RFPL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.