Predicted to enable microtubule binding activity. Involved in mitotic nuclear membrane reassembly. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for REEP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REEP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REEP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:21,918,240–21,920,671 | 222.3 kb | Distal (>10kb) Multiome | 727 | |
| chr8:22,009,978–22,010,924 | 131.5 kb | Distal (>10kb) Multiome | 885 | |
| chr8:22,024,029–22,025,514 | 116.6 kb | Distal (>10kb) Multiome | 508 | |
| chr8:22,036,665–22,037,480 | 104.9 kb | Distal (>10kb) Multiome HiCAR | 457 | |
| chr8:22,039,647–22,043,111 | 101.9 kb | Distal (>10kb) Multiome HiCAR | 407 | |
| chr8:22,047,856–22,051,849 | 92.7 kb | Distal (>10kb) Multiome | 566 | |
| chr8:22,052,727–22,057,283 | 87.9 kb | Distal (>10kb) Multiome | 541 | |
| chr8:22,066,266–22,067,293 | 75.0 kb | Distal (>10kb) Multiome | 612 | |
| chr8:22,069,764–22,070,311 | 71.8 kb | Distal (>10kb) Multiome | 85 | |
| chr8:22,089,006–22,089,746 | 52.7 kb | Distal (>10kb) Multiome | 562 | |
| chr8:22,095,301–22,095,802 | 46.3 kb | Distal (>10kb) Multiome | 199 | |
| chr8:22,108,625–22,110,515 | 32.4 kb | Distal (>10kb) Multiome | 907 | |
| chr8:22,129,779–22,131,071 | 11.4 kb | Distal (>10kb) Multiome | 440 | |
| chr8:22,137,231–22,137,850 | 4.4 kb | Proximal (<10kb) Multiome | 531 | |
| chr8:22,140,995–22,142,545 | 6 bp | At TSS Multiome | 753 | |
| chr8:22,156,517–22,157,091 | 14.9 kb | Distal (>10kb) Multiome HiCAR | 215 | |
| chr8:22,164,354–22,165,830 | 23.1 kb | Distal (>10kb) Multiome | 672 | |
| chr8:22,176,636–22,177,193 | 35.1 kb | Distal (>10kb) Multiome | 91 | |
| chr8:22,188,487–22,189,031 | 46.9 kb | Distal (>10kb) Multiome | 334 | |
| chr8:22,244,388–22,245,751 | 103.2 kb | Distal (>10kb) Multiome | 1013 | |
| chr8:22,275,120–22,276,011 | 133.5 kb | Distal (>10kb) Multiome | 195 | |
| chr8:22,365,087–22,366,071 | 223.7 kb | Distal (>10kb) Multiome | 444 | |
| chr8:22,366,837–22,368,383 | 225.4 kb | Distal (>10kb) Multiome | 859 | |
| chr8:22,440,466–22,441,769 | 299.2 kb | Distal (>10kb) Multiome | 784 |
Genomic view of the REEP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.