The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for RBPMS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBPMS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBPMS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,588,906–64,589,753 | 186.2 kb | Distal (>10kb) Multiome | 112 | |
| chr15:64,634,613–64,635,221 | 140.7 kb | Distal (>10kb) Multiome | 309 | |
| chr15:64,699,707–64,700,384 | 75.5 kb | Distal (>10kb) Multiome | 205 | |
| chr15:64,702,680–64,704,073 | 72.3 kb | Distal (>10kb) Multiome | 747 | |
| chr15:64,774,034–64,774,355 | 1.2 kb | Proximal (<10kb) | 106 | |
| chr15:64,774,780–64,776,025 | 41 bp | At TSS Multiome | 323 | |
| chr15:64,776,175–64,776,789 | 1.0 kb | Proximal (<10kb) Multiome | 105 | |
| chr15:64,780,613–64,781,099 | 5.2 kb | Proximal (<10kb) Multiome | 74 | |
| chr15:64,807,123–64,808,403 | 32.3 kb | Distal (>10kb) Multiome HiCAR | 248 | |
| chr15:64,808,791–64,809,297 | 33.5 kb | Distal (>10kb) Multiome HiCAR | 89 | |
| chr15:64,809,806–64,810,371 | 34.5 kb | Distal (>10kb) Multiome | 298 | |
| chr15:64,823,825–64,824,470 | 48.5 kb | Distal (>10kb) Multiome | 206 | |
| chr15:64,825,130–64,826,273 | 50.2 kb | Distal (>10kb) Multiome | 784 | |
| chr15:64,840,757–64,843,201 | 66.1 kb | Distal (>10kb) Multiome | 732 | |
| chr15:64,893,790–64,894,635 | 118.6 kb | Distal (>10kb) Multiome | 506 | |
| chr15:64,905,276–64,905,958 | 130.0 kb | Distal (>10kb) Multiome | 362 | |
| chr15:64,911,481–64,912,188 | 136.2 kb | Distal (>10kb) Multiome | 308 | |
| chr15:64,915,576–64,916,281 | 140.3 kb | Distal (>10kb) Multiome | 115 | |
| chr15:64,989,345–64,990,371 | 214.3 kb | Distal (>10kb) Multiome | 859 | |
| chr15:65,028,915–65,029,974 | 254.0 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,049,359–65,049,794 | 273.9 kb | Distal (>10kb) Multiome | 267 | |
| chr15:65,067,081–65,068,384 | 292.5 kb | Distal (>10kb) Multiome | 131 |
Genomic view of the RBPMS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.