Enables RNA binding activity. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RAVER2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAVER2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAVER2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:64,450,715–64,451,728 | 293.7 kb | Distal (>10kb) Multiome | 57 | |
| chr1:64,469,546–64,472,193 | 274.9 kb | Distal (>10kb) Multiome | 554 | |
| chr1:64,472,765–64,473,665 | 272.0 kb | Distal (>10kb) Multiome | 157 | |
| chr1:64,493,667–64,494,488 | 251.0 kb | Distal (>10kb) Multiome | 149 | |
| chr1:64,497,529–64,498,004 | 247.4 kb | Distal (>10kb) Multiome | 118 | |
| chr1:64,505,168–64,506,620 | 239.4 kb | Distal (>10kb) Multiome | 439 | |
| chr1:64,517,506–64,518,244 | 227.4 kb | Distal (>10kb) Multiome | 61 | |
| chr1:64,518,558–64,519,419 | 226.0 kb | Distal (>10kb) Multiome | 215 | |
| chr1:64,595,748–64,596,671 | 148.9 kb | Distal (>10kb) Multiome | 295 | |
| chr1:64,598,051–64,598,626 | 146.8 kb | Distal (>10kb) Multiome | 105 | |
| chr1:64,744,324–64,746,086 | 99 bp | At TSS Multiome | 695 | |
| chr1:64,965,270–64,967,021 | 221.5 kb | Distal (>10kb) Multiome | 764 | |
| chr1:65,002,269–65,003,167 | 257.7 kb | Distal (>10kb) Multiome | 584 |
Genomic view of the RAVER2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.