Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RANBP6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RANBP6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RANBP6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:5,831,978–5,833,476 | 182.6 kb | Distal (>10kb) Multiome | 896 | |
| chr9:5,885,989–5,886,773 | 129.3 kb | Distal (>10kb) Multiome HiCAR | 419 | |
| chr9:6,006,744–6,008,942 | 7.3 kb | Proximal (<10kb) Multiome | 899 | |
| chr9:6,015,337–6,016,019 | 56 bp | At TSS Multiome | 705 | |
| chr9:6,019,653–6,020,446 | 4.0 kb | Proximal (<10kb) | 46 | |
| chr9:6,021,445–6,021,997 | 6.1 kb | Proximal (<10kb) Multiome | 90 | |
| chr9:6,024,039–6,024,407 | 8.4 kb | Proximal (<10kb) | 151 | |
| chr9:6,049,327–6,050,383 | 34.4 kb | Distal (>10kb) Multiome | 170 | |
| chr9:6,080,023–6,081,094 | 64.8 kb | Distal (>10kb) Multiome | 455 |
Genomic view of the RANBP6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.